Annual Report 2022

Annual Report 2022

Non-Executive Directors

Our Board of Directors as of December 31, 2022 comprised the following eight non-executive directors:

Peter K. M. Verhaeghe

Peter K. M. Verhaeghe (photo)

Peter Verhaeghe has served as a member and chairperson of the board of arGEN-X B.V. since October 2008 and as non-executive director on our Board of Directors since July 2014. Mr. Verhaeghe is the managing partner of VVGB Advocaten-Avocats, a corporate finance law and tax law firm, a position he has held since July 1999. He is currently lead counsel to a number of Belgian, Dutch, French, U.S. and Swiss life sciences companies. Mr. Verhaeghe also serves on the board of directors of Participatiemaatschappij Vlaanderen NV since May 2018, as chairman of the board of Haretis SA (Luxembourg) since March 2011, and as member of the board of directors of miDiagnostics since April 2020. Mr. Verhaeghe also serves as the chairman of the LP & advisory committee of Bioqube Factory Fund I NV. Mr. Verhaeghe served as the president of the board of directors of Merisant France SAS, as a member of the management board of Merisant Company 2 sàrl and as a member of the board of directors of CzechPak Manufacturing s.r.o. He previously also served as director of Innogenetics NV (Belgium), Tibotec-Virco NV, Biocartis SA, and as the chairman of the board of directors of PharmaNeuroBoost NV and as liquidator in charge of KBC Private Equity Fund Biotech NV from April 2009 to December 2012. Mr. Verhaeghe holds a degree in law (J.D.) from the University of Leuven and an LL.M. degree from Harvard Law School. At the annual General Meeting held on May 10, 2022 (2022 Annual Meeting), he was reappointed for a new term of 2 years.

Dr. Werner Lanthaler (until February 27, 2023)

Dr. Werner Lanthaler (photo)

Dr. Werner Lanthaler has served as a member of our Board of Directors from July 2014 until February 27, 2023. Dr. Lanthaler is the CEO of Evotec SE, a global drug discovery and development organization, a position he has held since March 2009. He also serves on the supervisory board of AC Immune SA (Switzerland). Dr. Lanthaler previously served on the supervisory boards of Bioxell SpA and Pantec Biosolutions AG. Dr. Lanthaler holds a degree in psychology, a Ph. D. in business administration from Vienna University of Economics and Business and a Master’s degree in public administration from Harvard University. The Board of Directors nominated Mr. Lanthaler for re-appointment for a term of an additional 2 years during our 2022 General Meeting. Such reappointment beyond the first 8 years on our Board of Directors was deemed in the best interest of the Company, to allow for the successful selection, appointment and onboarding of Mr. Lanthaler’s successor. Mr. Lanthaler resigned from our Board of Directors following our board meeting of February 28, 2023 upon appointment and onboarding of Mr. Krognes, who was appointed as a non-executive director of the Company and chairperson of the Company’s audit and compliance committee.

Mr. Steve Krognes (effective February 27, 2023)

Mr. Steven Krognes (photo)

Mr. Krognes serves as a member of our Board of Directors and as a chairperson of our audit and compliance committee since February 27, 2023. Mr. Krognes also serves on the boards of directors of Guardant Health, Inc., Denali Therapeutics, Inc., and Gritstone bio, Inc. He previously served on the board of directors of RLS Global AB and Corvus Pharmaceuticals, Inc. Mr. Krognes was the chief financial officer of Denali Therapeutics, Inc., from 2015 until retiring from that position in April 2022. Steve joined Denali Therapeutics, Inc., as the founding chief financial officer, building and leading the finance team as well as supervising the IT and facilities functions. He led successful financings for Denali Therapeutics, Inc., including the initial public offering in 2017, and has contributed significantly to the company’s strategy, growth and strong financial position. His extensive leadership experience in the biotech and pharmaceutical industry includes 12 years in total at Roche and Genentech, Inc., serving as chief financial officer of Genentech, Inc., for six years and global head of Roche’s mergers & acquisition team for six years. He chaired the Genentech Access to Care Foundation and represented Genentech on the board and executive committee of the California Life Science Association. Before that, he worked as an investment banker at Goldman Sachs, as a management consultant at McKinsey & Company, and as a venture capitalist in Scandinavia. Mr. Krognes holds a master’s in business administration (MBA) from Harvard Business School and a Bachelor of Science in economics from the Wharton School of the University of Pennsylvania.

Dr. J. Donald deBethizy

Dr. J. Donald deBethizy (photo)

Dr. J. Donald deBethizy has served as a member of our Board of Directors since May 2015. Dr. deBethizy has 30 years of experience in research and development and financial, business and operating management and board work in the biotechnology and consumer products industry. He is the president of White City Consulting ApS an executive coaching company. He currently serves on the supervisory boards of Lophora ApS, Newron Pharmaceuticals SpA, Proterris, Inc. and a board advisor for NDA Regulatory Service AB. Previously, Dr. deBethizy served as president and CEO of Santaris Pharma A/S until October 2014, when the company was sold to Roche. From August 2000 to June 2012, Dr. deBethizy was co-founder and CEO of Targacept, Inc. (Targacept), a U.S. biotechnology company listed on Nasdaq. From May 2013 to November 2014, he served as executive chairman of Contera Pharma ApS until it was sold to Bukwang Pharma (Korea), and from July 2015 to November 2017, he served as chairman of Rigotec GmbH until it was sold to Merck, Inc. He previously served on the boards of Albumedix Ltd (Chair, company sold to Sartorius AG in September 2022), Saniona AB (Chair), Asceneuron SA, TME Pharma NV (Chair, TME NV and AG), Serendex Pharmaceuticals A/S, Enbiotix, Inc., Targacept, Ligocyte Pharmaceuticals until it was sold to Takeda Pharmaceutical Co Ltd and Biosource, Inc. Dr. deBethizy has held adjunct appointments at Wake Forest University Babcock School of Management, Wake Forest University School of Medicine and Duke University. Dr. deBethizy holds a B. Sc. in biology from the University of Maryland, and an M.Sc. and a Ph.D. in toxicology from Utah State University.

Dr. Pamela Klein

Dr. Pamela Klein (photo)

Dr. Pamela Klein has served as a member of our Board of Directors since April 2016. Dr. Klein is a principal and founder of PMK BioResearch, which offers strategic consulting in oncology drug development to corporate boards, management teams and the investment community, a position she has held since 2008. She currently serves as a member of the board of directors of several companies including F-Star Therapeutics, Inc., I-Mab and Patrys Ltd; as well as various scientific advisor boards. Previously, Dr. Klein served on the board of directors of Jiya Acquisition Corp. Dr. Klein also spent seven years at the National Cancer Institute as Research Director of the NCI-Navy Breast Center, after which she joined Genentech as Vice President, Development until 2001. She served as chief medical officer for Intellikine, Inc., which was acquired by Takeda American Holdings. Dr. Klein holds a Bachelor’s degree in biology from California State University and an M.D. from Stritch School of Medicine, Loyola University Chicago and is trained in internal medicine and medical oncology.

Anthony A. Rosenberg

Msc. Anthony A. Rosenberg (photo)

Anthony A. Rosenberg has served as a member of our Board of Directors since April 2017. He currently serves as CEO of TR Advisory Services GmbH, his own consultancy firm advising on business development, licensing and mergers and acquisitions. Mr. Rosenberg also currently serves on the boards of directors of SiO2 Material Science, Oculis SA (chairman) and Cullinan Oncology (chairman). Previously Mr. Rosenberg held the positions of Managing Director at MPM Capital, a venture capital firm (2015 until 2020); head of M&A and Licensing of Novartis International (2013 to 2015) and head of business development and licensing at Novartis Pharma (2005 to 2012). Mr. Rosenberg also previously served on the boards of directors at Radius Health, Inc., TriNetX, Inc., iOmx Therapeutics AG, and Clinical Ink. Msc. A.A. Rosenberg has a B.Sc. (Hons) from the University of Leicester and a M.Sc. Physiology from the University of London.

James M. Daly

James M. Daly (photo)

James M. Daly has served as a member of our Board of Directors since May 2018. He joined GlaxoSmithKline in 1985 where he held various positions, including sr. vice president – respiratory division with with full responsibility for sales, marketing and medical affairs. He moved to Amgen in 2002 where he was sr. vice president for the North America commercial operations 2011. In 2012, he joined Incyte Corp, a publicly-traded company focused on oncology and inflammation, where he was chief commercial officer until June 2015. Mr. Daly currently serves as a director of Acadia Pharmaceuticals, Inc., Halozyme, Bellicum Pharmaceuticals, Inc. and Madrigal Pharmaceuticals, Inc., all Nasdaq-listed companies. Mr. Daly holds a Bachelor of Science and an MBA from the University at Buffalo, State University of New York. He was reappointed for a new 4-year term at the 2022 General Meeting.

Camilla Sylvest

Camilla Sylvest (photo)

Camilla Sylvest was appointed as non-executive director on September 8, 2022 and brings strong strategic and operational leadership in the scaling of global commercial pharmaceutical organizations with a specific focus on company culture and sustainability. Camilla Sylvest currently serves as the executive vice president, commercial strategy & corporate affairs of Novo Nordisk A/S. Ms. Sylvest also serves as the vice chair of the World Diabetes Foundation Board and as a member of the board of directors of Danish Crown A/S. Camilla Sylvest has more than 25 years of working experience within Novo Nordisk A/S and was based in Switzerland, Denmark, Germany, Malaysia and the PRC.

Over the years, Camilla Sylvest headed up affiliates of growing size and complexity in Europe within Novo Nordisk A/S and she was also corporate vice president business area Oceania and Southeast Asia and senior vice president and general manager Novo Nordisk region China. Camilla Sylvest holds a Master of Science in Economics from the University of Odense, Denmark and an executive MBA from the Scandinavian Management Institute in Copenhagen, Denmark.

Ana Cespedes

Ana Cespedes (photo)

Ana Cespedes was appointed as non-executive director on December 12, 2022 and brings robust experience across a broad range of critical areas for commercialization and access, as well as for organizational effectiveness.

Ana Cespedes is the chief operating officer of the International AIDS Vaccine Initiative (IAVI), a global organization dedicated to developing accessible vaccines and antibodies for infectious diseases. Prior to joining IAVI, Ms. Cespedes held several roles at Merck KGaA, based in Boston, MA, most recently serving as senior vice president, global marketing & strategy. Ms. Cespedes founded and led the global market access and pricing function for the company and worked with stakeholders to communicate the clinical, economic, and societal value of innovative medicines. Prior to that, Ms. Cespedes led the first integrated corporate affairs group at Serono Iberia and Merck Spain, was managing director of the Spanish branch of the company’s nonprofit organization, and worked as a senior consultant at Arthur Andersen.

Ms. Cespedes is a founding member of the National Congress of Corporate Affairs in Spain, the London School of Economics Market Access Academy, and the Cooperation for Oncology Data. She is also the founder of Living Mindfulness S.L.

Ms. Cespedes holds a B.S. and a Pharm.D. from the Complutense University of Madrid, and an MBA from IESE Business School.

The following table sets forth certain information with respect to the current non-executive members of our Board of Directors, including their ages, as of December 31, 2022.

Name

 

Age

 

Gender

 

Position

 

Nationality

 

Date of Initial Appointment

 

Date of last (re-) Appointment

 

Term Expiration

Peter K. M. Verhaeghe

 

64

 

M

 

Non-Executive Director (chairperson)

 

Belgium

 

October 15, 2008

 

May 10, 2022

 

2026

Werner Lanthaler 1)

 

54

 

M

 

Non-Executive Director (vice-chairperson)

 

Austria

 

July 9, 2014

 

May 10, 2022

 

2024

J. Donald deBethizy

 

72

 

M

 

Non-Executive Director

 

U.S.

 

May 13, 2015

 

May 7, 2019

 

2023

Pamela Klein

 

61

 

F

 

Non-Executive Director

 

U.S.

 

April 28, 2016

 

May 12, 2020

 

2024

Anthony A. Rosenberg

 

69

 

M

 

Non-Executive Director

 

UK

 

April 26, 2017

 

May 11, 2021

 

2025

James M. Daly

 

61

 

M

 

Non-Executive Director

 

U.S.

 

May 8, 2018

 

May 10, 2022

 

2026

Camilla Sylvest

 

50

 

F

 

Non-executive director

 

Denmark

 

September 8, 2022

 

September 8, 2022

 

2026

Ana Cespedes

 

49

 

F

 

Non-executive director

 

Spain

 

December 12, 2022

 

December 12, 2022

 

2026

1)

Werner Lanthaler resigned effective February 27, 2023 and was succeeded by Steve Krognes effective February 27, 2023 whose term will expire at our 2027 annual General Meeting.

The address for our non-executive directors is our registered office, Laarderhoogtweg 25, 1101 EB Amsterdam, the Netherlands.

Steve Krognes was appointed at an extraordinary General Meeting on February 27, 2023. Peter K.M. Verhaeghe, and James M. Daly were re-appointed at the 2022 General Meeting.

The following table sets forth the companies and partnerships of which the current non-executive members of our Board of Directors have been a member of the administrative, management or supervisory bodies or partner at any time in the previous five years, indicating whether or not the individual is still a member of the administrative, management or supervisory bodies or partner, as of the date of this Annual Report, other than argenx or our subsidiaries:

Name

 

Current

 

Past

Peter K. M. Verhaeghe

 

VVGB Advocaten – Avocats

 

PharmaNeuroBoost NV

 

 

Haretis SA

 

Biocartis SA

 

 

Participatiemaatschappij Vlaanderen NV

 

Fujirebio Europe NV (formerly Innogenetics NV)

 

 

miDiagnostics NV

 

Tibotec-Virco NV

 

 

Bioqube Factory Fund I NV

 

Merisant France SAS

 

 

 

 

Merisant Company 2 sàrl

 

 

 

 

CzechPak Manufacturing s. r. o.

 

 

 

 

Bever Zwerfsport BV

 

 

 

 

 

Werner Lanthaler 1)

 

Evotec SE

 

Bioxell SpA

 

 

AC Immune SA

 

Pantec Biosolutions AG

 

 

 

 

 

J. Donald deBethizy

 

White City Consulting ApS

 

Rigotec GmbH

 

 

Newron Pharmaceuticals SpA

 

TME Pharma NV and AG

 

 

Protteris, Inc.

 

Saniona AB

 

 

Lophora ApS

 

Albumedix A/S

 

 

Albumin Holdings ApS

 

Asceneuron SA

 

 

Innovent LLC

 

 

 

 

 

 

 

Pamela Klein

 

PMK BioResearch

 

Olema Oncology

 

 

Patrys Limited

 

Jiya Acquisition Corp.

 

 

I-Mab

 

 

 

 

F-Star Therapeutics, Inc.

 

 

 

 

 

 

 

Anthony A. Rosenberg

 

Cullinan Oncology, Inc.

 

Radius Health, Inc.

 

 

Oculis SA

 

TriNetX, Inc.

 

 

TR Advisory Services GmbH

 

Clinical Ink, Inc.

 

 

 

 

iOmx Therapeutics AG

 

 

 

 

MPM Capital

 

 

 

 

SiO2 Material Science

 

 

 

 

 

James M. Daly

 

Acadia Pharmaceuticals, Inc.

 

Chimerix, Inc.

 

 

Halozyme Therapeutics, Inc.

 

 

 

 

Bellicum Pharmaceuticals, Inc.

 

 

 

 

Madrigal Pharmaceuticals

 

 

 

 

Coherus Biosciences

 

 

 

 

 

 

 

Camilla Sylvest

 

Novo Nordisk

 

 

 

World Diabetes Foundation

 

 

 

 

Crown A/S

 

 

 

 

 

 

 

Ana Cespedes

 

Instituto ProPatients

 

Merck KGaA

 

 

 

 

Merck Spain

 

 

 

 

Serono Iberia

 

 

 

 

Arthur Andersen

 

 

 

 

 

Steve Krognes

 

Denali Therapeutics, Inc.

 

R/S Global

 

 

Guardant Health, Inc.

 

Corvus Pharmaceuticals, Inc.

 

 

Gritstone bio, Inc.

 

 

1)

Werner Lanthaler resigned effective February 27, 2023 and was succeeded by Steve Krognes effective February 27, 2023 whose term will expire at our 2027 annual General Meeting.